In recent years, the areas of use of PRP application have become increasingly diverse. IVF treatment has also become among the use cases of PRP application. The method, which is based on injecting the platelet-rich fluid obtained as a result of special processes of the blood taken from the person into the treatment area, stands out with its advantages such as tissue repair and cell renewal.
PRP therapy, which does not cause any allergic reaction due to the fact that it is completely from the person's own blood, can be applied to the uterus and ovaries in selected patients. The main goal is to accelerate tissue repair and achieve tissue rejuvenation. PRP applications, which can be preferred in order to increase the success rate of IVF treatment, can provide effective results.
The main goal of IVF treatment is to create quality embryos. Egg quality is an extremely important requirement in the formation of quality embryos. PRP treatment for egg rejuvenation may be recommended for women who have not been able to obtain quality embryos in previous trials or who have failed embryo implantation history.
The application of PRP to the ovaries ensures the delivery of growth factors to the ovaries. With this adjunctive treatment, which does not cause any change in the basic stages of IVF treatment, it is aimed to rejuvenate the ovaries. Ovarian rejuvenation treatment performed under the guidance of transvaginal ultrasound can be applied to women with low egg reserves, low AMH levels, low egg quality, early ovarian failure, and a history of more than one unsuccessful IVF, to stimulate the ovaries.
The final stage of IVF treatment is embryo transfer. After the embryos obtained by combining the mature egg cells taken from the woman with the sperm taken from the man or by injecting the sperm directly into the egg are transferred to the uterus, the couples wait for the pregnancy to occur. The formation of pregnancy occurs with the implantation of embryos into the uterus. The characteristics of the uterine wall can affect the retention of the embryo.
Scientific studies have shown that the thickness of the endometrium is one of the most important elements for implantation and pregnancy, and the minimum endometrial thickness required for embryo transfer is 7 mm. A thickness of less than 7 mm, which is associated with a low probability of pregnancy during IVF cycles, is considered a thin endometrial thickness.1
If the uterine wall is not thick enough, embryo implantation and / or the development of implanted embryos may fail. In women with a thin endometrial layer, the probability of obtaining positive results may increase by resorting to intrauterine PRP application.
PRP application stands out among the treatment methods that can be preferred to increase the inner layer of the uterus to a sufficient thickness. It can be applied to women with endometrial thickness below 6 mm. After the application, the endometrium response is checked. The measurement of the inner layer of the uterus is performed approximately 48 hours after the targeted PRP application.
For women who have a thin inner layer of the uterus or who have a history of two or more failed IVF treatments, intrauterine rejuvenation therapy can be performed with PRP.
1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558624/
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